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Senolytic Activator

Category: Anti-aging


Combat cellular senescence

  • Helps the body manage senescent cells
  • Promotes youthful, healthy cellular function
  • Supports systemic rejuvenation
  • Innovative formula made with black tea theaflavins, highly absorbable quercetin, and apigenin
  • Convenient once-a-week dosing

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More info

Item Catalog Number: 02301

24 vegetarian capsules

NON GMO Product

Cellular senescence is a natural part of the aging process in which cells no longer function optimally. Senescent cells can accumulate over time, affecting the day-to-day function of the healthy cells around them. Senolytic compounds selectively target senescent cells.

Black tea theaflavins, quercetin and apigenin target specific biological pathways, helping to manage senescent cells.

Benefits at a glance:

  • Helps the body manage senescent cells
  • Promotes youthful, healthy cellular function
  • Supports systemic rejuvenation
  • Innovative formula made with black tea theaflavins, highly absorbable quercetin, and apigenin
  • Convenient once-a-week dosing

New research indicates that black tea theaflavins and quercetin target specific biological pathways, making it easier for the body to manage senescent cells.2-4

Theaflavins reduce senescent cell burden

Theaflavins are compounds derived from Camellia sinensis (tea plant). These compounds have widespread health benefits, supporting healthy cell division and healthy inflammatory response.5,6

New research indicates that theaflavins may be especially helpful for reducing senescent cell burden. In pre-clinical models, theaflavins helped powerfully inhibit the accumulation of particular cell senescence biomarkers.2

Quercetin promotes cellular health and more

Quercetin supports endothelial and cardiovascular health, promotes healthy immune function and more.7,8 The value of quercetin has been recognized for some time. But its potential to meaningfully impact whole body rejuvenation is just starting to be uncovered through its senolytic activity. The discovery that quercetin is a senolytic compound has drawn significant attention to this innovative approach to combat aging.4

Better absorption than standard types of quercetin

Standard quercetin is hard to absorb. But this formulation features our new quercetin phytosome, a phospholipid sphere that encases the quercetin, aiding in its absorption and making it up to 50 times more bioavailable.


Life Extension has identified apigenin, a natural flavonoid, as a powerful addition to our Senolytic Activator formula. Quercetin and theaflavins from black tea target senescent cells, but not all of them.

The remaining senescent cells create compounds known collectively as Senescence Associated Secretory Phenotype, or SASP.9 Apigenin helps inhibit remaining senescent cells from making SASP to support cellular and tissue health—a critical aspect of healthy aging.10

Convenient, once-weekly formula

For those who aren’t keen on adding another supplement to their regimen, here’s good news: Senolytic research indicates that intermittent dosing in pre-clinical studies is effective at improving healthspan.4 So, Senolytic Activator instructions call for taking just two vegetarian capsules, once a week.

Manage senescent cells, promote healthy cellular function and support overall longevity with Senolytic Activator.

Supplement Facts

Serving Size 2 vegetarian capsules
Servings Per Container 12

Amount Per Serving
Theaflavins [from decaffeinated black tea extract (leaf)] 275 mg
Bio-Quercetin phytosome (providing 25 mg quercetin [from Japanese sophora concentrate (flower bud)], phosphatidylcholine complex [from sunflower]) 74 mg


50 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate.


Dosage and Use
  • Take two (2) capsules once weekly, with or without food, or as recommended by a healthcare practitioner.


  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Exp Gerontol. 2015;68:19-25
  2. Free Radic Biol Med. 2017;113:59-70.
  3. Pharmacol Res. 2012;66(4):363-73.
  4. Aging Cell. 2015;14(4):644-58.
  5. Oxid Med Cell Longev. 2009;2(5):270-8.
  6. Cardiovasc Res. 2007;73(2):348-58.
  7. Nutrients. 2016;8(3):167.
  8. Trends in Food Science & Technology. 2016;56:21-38.
  9. Nat Med. 2015;21(12):1424-35.
  10. Biochem Pharmacol. 2015;96(4):337-48.


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