Science-based food supplements
Science-based food supplements
  • TMG (Trimethylglycine)

    Promotes a healthy heart

    • It is a “methyl donor,” providing extra methyl groups to hasten the conversion of homocysteine back to methionine
    • Research shows TMG’s ability to promote healthy levels of homocysteine

    Retail price: 16.66 
    Your price: 12.50  (-25.00%)

    Volume discount:

    Quantity: 1 2 -3 4 +
    Unit price after discount: 12.50  11.87  11.25 

    In stock

    SKU: 01859 Categories: , , Tags: , ,



500 mg, 60 liquid vegetarian capsules

Item Catalog Number: 01859

Trimethylglycine (TMG) is also called glycine betaine, but the name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine. TMG was discovered to be beneficial to heart health back in the 1950s.1-5 TMG operates along a pathway similar to that of vitamin B12. It is a “methyl donor,” providing extra methyl groups to hasten the conversion of homocysteine back to methionine.6 When a TMG methyl group is donated to a molecule of homocysteine, it converts to the non-toxic amino acid, methionine.7,8 Research showing TMG’s ability to promote healthy levels of homocysteine, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health.9-17 For example, in a recent cross-sectional survey study, participants who consumed >360 mg/d of TMG had, on average, 10% lower concentrations of homocysteine and 19% lower concentrations of C-reactive protein than those participants who consumed <260 mg/d.18

Supplement Facts

Serving Size 2 vegetarian liquid capsules

Servings Per Container 30

Amount Per Serving
Trimethylglycine (TMG) (as betaine anhydrous) 1000 mg
Other ingredients: glycerin, vegetable cellulose (capsule), purified water.

Dosage and Use

Take two (2) capsules in the morning with or without food, or as recommended by a healthcare practitioner.
TMG should be taken with co-factors B6, B12, and folic acid.


If muscle tension or headaches occur, reduce the dose or discontinue product, and inform your physician if they do not subside.


Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

    1. Ann West Med Surg. 1951;5:825-9.
    2. Ann West Med Surg. 1951;5:830-55.
    3. Ann West Med Surg. 1951;5:856-62.
    4. JAMA. 1951;145:1232-6.
    5. Am J Dig Dis. 1952;19:381-4.
    6. Mol Genet Metab. 2006 Jul;88(3):201-7.
    7. Biochemistry. 1999 Oct 19;38(42):13991-8.
    8. Curr Drug Metab. 2005 Feb;6(1):15-22.
    9. J Nutr. 2003 Dec;133(12):4135-8.
    10. J Nutr. 2003 May;133(5):1291-5.
    11. Am J Clin Nutr. 2002 Nov;76(5):961-7.
    12. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
    13. Kidney Int. 2002 Mar;61(3):1040-6.
    14. An Esp Pediatr. 1993 Jul;39(1):37-41.
    15. Metabolism. 1985 Dec;34(12):1115-21.
    16. N Engl J Med. 1983 Aug 25;309(8):448-53.
    17. J Nutr. 2006 Jan;136(1):34-8.
    18. Am J Clin Nutr. 2008 Feb;87(2):424-30.


There are no reviews yet.

Be the first to review “TMG (Trimethylglycine)” is not responsible for the action and effects of the purchased product, which may vary depending on the body and health condition.
The results achieved may vary from person to person depending on individual factors.

Related products

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.

Copyright © 2019 All rights reserved. LEsupplements® is registered trademark of LifeExtensionIE Limited