Nutrients derived from plants have been shown to protect against changes in the brain that lead to neurological disorders. In 2021, two review articles identified fisetin as one of the most promising. Preclinical studies show the potential of fisetin to reduce the impact of stroke, mild cognitive impairment, and dementia.

KNOWLEDGE BASE
Here you can browse information and reports on many diseases and nutrients.
Choose from the menu the topic that interests you about the nutrient or health issue.
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How Dopamine Protects the Aging Brain
By preserving healthy dopamine levels, phellodendron bark may help maintain clear thinking and motivation—while reducing potential for neurodegenerative illnesses.
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How To Restore Your Cellular Energy with D-ribose
D-ribose replenishes the metabolic energy needed by all our cells—including those in our heart and brain—thereby improving cardiac and neurological function and vitality.
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What’s in Mushrooms That Supports Healthy Aging?
Increased mushroom consumption has been found to lower mortality risk. A specific mushroom compound is associated with enhanced longevity, reduced telomere shortening, and DNA repair.
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A Longer-Lasting Vitamin C
A new liposomal hydrogel formula increased vitamin C blood levels nearly seven times greater than regular vitamin C and kept them higher far longer.
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Boost Testosterone Without Drugs
As men age, their testosterone tends to bind to a blood protein rendering the testosterone unavailable to cells throughout the body. A plant-based formula increased free testosterone by 48% in a human study.
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A Solution for Brain Fog
We all have moments when we feel mentally fatigued and find it hard to concentrate. This is often referred to as brain fog. Until recently, it was believed that little could be done about it. But by studying various medical conditions associated with brain fog, scientists have pinpointed biological alterations in the brain that may cause these feelings of decreased mental energy and sharpness.
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A Brain-Specific Magnesium Relieves Stress
Chronic stress can be worsened by low levels of magnesium. A new form of magnesium has been shown to produce a brain-calming effect.
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Protect Your Respiratory System
NAC (N-acetyl-L-cysteine) helps prevent viruses and bacteria from adhering to the lining of the lungs. Data show that NAC reduces excess airway mucus, lowers inflammation, supports pulmonary function, and inhibits infectious colonization.
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Prebiotics for Better Health
In a clinical trial at UCLA School of Medicine, researchers found that the prebiotic XOS (xylooligosaccharide) increased the beneficial bifidobacteria for overall health.
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Superoxide Dismutase Boosting
The enzyme superoxide dismutase (SOD) is one of the body’s foremost antioxidant defenses, reducing free radical damage associated with atherosclerosis, stroke, and arthritis. New bioavailable forms of SOD offer superior protection against oxygen free radicals.
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N-acetylcysteine (NAC)
The amino acid derivative N-acetylcysteine protects against a broad array of environmental toxins, helps boost the body’s immune system, and confers other health-promoting benefits.
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Reducing the Risks of High Cortisol
Your body releases the hormone cortisol in response to stress. Excess cortisol from chronic stress is linked to everything from diabetes to bone loss, weight gain, and sleepless nights. A low-cost supplement called rhodiola combats cortisol’s lethal effects.
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Is Soy Safe? Busting the Myths of a Nutritional Powerhouse
Is soy safe? A vocal minority has fueled a “controversy” of misinformation that surrounds this nutritional powerhouse. A review of the published scientific literature uncovers a wealth of studies validating soy’s broad-spectrum benefits, from cardiovascular disease and cancer prevention, to helping to maintain bone density.
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Detoxifying Effects of Lycopene
A recent review reveals that lycopene shields against environmental and food toxins. Individuals with the highest lycopene concentrations have a 37% lower mortality risk.
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Lethal Dangers of Sitting Too Long
Deep vein thrombosis, caused by sitting too long, kills over 100,000 Americans each year. A human study shows that nattokinase and French maritime pine bark improve circulation in the lower legs, lessen leg swelling, and reduce thrombosis (abnormal clot) formation.
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Restore Youthful Cell Function via Autophagy
With age, the insides of our cells accumulate damaged proteins and other debris that impair youthful function. Humans are equipped with a built-in process that removes these toxic waste products to make room for healthy internal regeneration. This natural, cell housekeeping process is called autophagy.
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Restore healthy stem cell function
Using deep-learning artificial intelligence, scientists have identified three plant-based nutrients that can help reverse age-related damage to our existing pool of stem cells.
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Boswellia, An Effective Pain Relief
Low-level inflammation is an underlying factor for six of the ten leading causes of death. Studies have shown that Boswellia extract significantly improved arthritis patients’ pain and function in just seven days while suppressing causative agents involved in chronic inflammation.
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Brain Protection from New Form of Vitamin B12
Two active forms of vitamin B12 offer support to the aging brain. Preclinical data shows one of the forms protects dopamine levels. People with vitamin B12 deficiencies frequently suffer anemia, weakness, and fatigue. But there are more dangerous effects. Low vitamin B12 levels have been associated with progressive brain atrophy (shrinkage). One study found an astounding 517% greater rate of brain volume loss in people with lower vitamin B12 than those with higher B12 levels.
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Homocysteine Reduction
Homocysteine is an amino acid made from a common dietary amino acid, methionine, that inflicts damage to the inner arterial lining (endothelium). Elevated levels of homocysteine have been associated with many diseases, including: cardiovascular disease, congestive heart failure, stroke, migraines, age-related macular degeneration, hearing loss, brain atrophy, Alzheimer disease.
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How Ionic Zinc Can Stop Colds Fast
A study showed that lozenges containing zinc acetate are best at curbing a cold and shortening its duration. Zinc lozenges are not meant for everyday use. Common colds are the most common human infection. Based on research published in the 1980s, many people know to start popping zinc lozenges. But not all zinc is the same. Many cold lozenges feature different forms of zinc that are not the most effective choice.
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Lactoferrin Helps Protect Against Viruses
Lactoferrin, a protein found in mother’s milk, shows antiviral activity in preclinical trials. It impedes viral binding to cell membranes, while activating immune defenses.
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New, dangerous coronavirus (SARS-CoV-2, COVID-19) Nutritional recommendations when facing coronavirus pandemic.
While medical science is diligently working on the development of an effective treatment, it may be prudent to learn about some protective measures now, and to become informed concerning potential nutritional therapies.
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LEsupplements.com Project
The Life Extension Foundation offers several hundred products. Thinking about the offer of the LEsupplements.com portal I focused on the most advanced ones and these formulas which are dedicated to specific diseases.